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Spontaneous Erections/Priapism: Given the nature of PT-141, one might wonder about priapism (erections lasting too long)

By targeting genes linked to fatty acid synthesis and oxidative stress, a lower amount of deconjugated bile acid can further reduce taurine production and cause hepatic steatosis and inflammation (133)

Depletion of beneficial taxa such as Odoribacter (Bacteroidetes) and Lachno Clostridium (Firmicutes), along with increased abundance of pro-inflammatory taxa including Ileibacterium and Olsenella , was associated with reduced SCFA gene expression, downregulation of tight junction proteins (occludin and claudin-1), and microglial activation in the amygdala and arcuate nucleus, indicating gut barrier disruption and neuroinflammation that coincided with anxiety-like behavior

A notable limitation was that 82% of patients developed anti-drug antibodies and 10% exhibited neutralizing antibodies, which could potentially compromise treatment efficacy and tolerability